Acyl Coenzyme A Synthetase Regulation: Putative Role in Long-Chain Acyl Coenzyme A Partitioning
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چکیده
منابع مشابه
Studies on acetyl-coenzyme A synthetase of yeast: inhibition by long-chain acyl-coenzyme A esters.
Long-chain acyl-coenzyme A (CoA) compounds (palmityl, stearyl, and oleyl) were found to be potent inhibitors of acetyl-CoA synthetase (ACS) of Saccharomyces cerevisiae strain LK2G12 from aerobic, but not from nonaerobic, cells. The effectiveness of the inhibitors of the aerobic enzyme was in the following order: palmityl-CoA < stearyl-CoA < oleyl-CoA. Short-chain acyl-CoA compounds (propionyl, ...
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amino acids. In prolonged starvation it is known that ketonebody utilization by tissues such as brain increases whereas hepatic gluconeogenesis from amino acids is greatly suppressed. This decline in amino acid utilization is accompanied by a decrease in extrahepatic proteolysis and release of glucogenic amino acids such as glutamine and alanine. The inverse relationship between blood ketone-bo...
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Fatty acid oxidation (FAO) defects are inborn errors of metabolism clinically associated with cardiomyopathy and sudden infant death syndrome (SIDS). FAO disorders often present in infancy with myocardial dysfunction and arrhythmias after exposure to stresses such as fasting, exercise, or intercurrent viral illness. It is uncertain whether the heart, in the absence of stress, is normal. We gene...
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The fatty acid transport proteins (FATP) and long-chain acyl coenzyme A synthetase (ACSL) proteins have been shown to play a role in facilitating long-chain fatty acid (LCFA) transport in mammalian cells under physiologic conditions. The involvement of both FATP and ACSL proteins is consistent with the model of vectorial acylation, in which fatty acid transport is coupled to esterification. Thi...
متن کاملLong-chain acyl-coenzyme A synthetase activity of spinach chloroplasts is concentrated in the envelope.
Purified chloroplasts were disrupted and then fractionated by discontinuous sucrose-density-gradient centrifugation. Envelopes contained long-chain acyl-CoA synthetase at a specific activity 80 times the activity in the lamellae or the stroma. Acetyl-CoA synthetase was concentrated in the stroma, and chlorophyll was confined to the lamellae membranes. Phospholipase D was not detected in any fra...
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ژورنال
عنوان ژورنال: Obesity Research
سال: 2004
ISSN: 1071-7323
DOI: 10.1038/oby.2004.221